The PL-ELS 2100 surpasses other ELSDs for low
temperature HPLC applications with semi-volatile
compounds.
The PL-ELS 2100 represents the next generation
of ELSD technology. Its innovative design provides
optimum performance across a diverse range of
HPLC applications. This patented design permits
operation at very low temperatures, even ambient,
to facilitate the detection of semi-volatile
compounds not seen by other ELSDs.
In ELSDs, the eluent is removed as it passes
through the evaporator tube. The temperature
of this tube is critical in optimizing the detection
of small molecules. If the temperature is too
high, thermally labile compounds in the sample
may evaporate along with the eluent and will
not be detected. The PL-ELS 2100 can evaporate
high boiling solvents at very low temperatures,
for example, a mobile phase consisting of 100%
water at 30°C. The novel design (patent pending)
of the PL-ELS 2100 provides superior performance
compared to competitors' detectors for the analysis
of semi-volatile compounds.
PL-ELS 2100 Applications
Analysis of Parabens
This application shows a separation of parabens,
synthetic preservatives frequently used in cosmetics
and personal care products and in pharmaceutical
formulations. These low molecular weight compounds
are relatively volatile but can easily be detected
by operating the PL-ELS 2100 at very low temperatures,
in this case, 30°C.
